Selenium is a micronutrient essential for mammals. It plays a crucial role in the mammalian defense system against oxidative stress, since it is essential for the activity of glutathione peroxidase (GPx). It is also essential for the activity of various enzymes such as thioredoxin reductase, iodothyronine deiodinase, selenophosphate synthetase and selenoprotein P [1]. Moreover, some organoselenium compounds are known as effective insecticides, microbicides [2], prooxidants [3] and antimycobacterial agents [4]. hDeutee rotocy coliucr syinstteermesst, ifno rt hteh ep ressyenntht epsriost oocof l,s seelelennoopphheennso [a3n,2d- ds]peylerinmoildoicnoen (d1e)n wceads synthesized and subsequently treated with POCl3 and hydrazine hydrate to give compound (2). The hydrazinated compound (2) on treatment with CS2 and csourbrseesqpuoenndtilnyg v daerisoiuresd a Slk-yall khyalalidteeds sienl ethneo pphreesneon[2c,e3 -oef] [N1,a2H,4 ]itnr iaDzMolFo,[ 4c,o3n-cv]epryteridm itdoi nthees (3a-e).

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