چهاردهمین کنگره بین المللی سلول های بنیادی رویان , 2018-08-29

Title : ( Targeted Delivery of Medicinal Products in Advanced Therapy using Cellular Knowledge Seeding )

Authors: , Mohammad Reza Akbarzadeh Totonchi ,

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Abstract

Advanced Therapy Medicinal Products (ATMPs) are innovative therapies that include gene therapy, somatic cell therapy, and tissue-engineered products. One of the important principle in the ATMPs is the delivery process of gene, cell, engineered tissue, and drug at the right time to the right place in the body. In order to handle delivery process especially to the critical organs e.g. brain that have Blood Brain Barrier (BBB), there is a great need for using intelligent delivery devises. In this paper, we introduce a swarm of nano carriers for collective detecting, and doing targeted delivery using cellular knowledge seeding which is defined in the synergy of artificial intelligence and biology. Here, each spot of the environment is a full laboratory for detecting disease marker, and the synergistic integration of spots' information will lead to a holistic diagnosis of the disease. Using online machine learning technique, this concept is implemented, and the carriers of the medicinal products using a swarm control are guided toward the inferred target. Result show the merits of the proposed method in targeted cancer drug delivery. Literature review ATMPs as the current alternative therapy present in a good body of literature. It is based on three basic elements of biomaterials, cells and growth factors. Several ATMPs' application include the usage of the cell-based medicinal products for type-1-diabetes treatment, bone repair, cardiac repair, and cancer treatment. Evaluation of cell therapies in different countries and its challenges are also another part of studies in this realm. Conclusion ATMPs as innovative therapies provide a wide range of applications in the case that normal therapies are not effective. ATMPs use carriers for medicinal products delivery. This autonomous navigation use collective knowledge of the disease microenvironment for detection and therapy. In this paper swarm of these carriers are used for targeted delivery.

Keywords

, Targeted Delivery, Advanced therapy medicinal products, Knowledge Seeding, Artificial Intelligence.
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@inproceedings{paperid:1070855,
author = {, and Akbarzadeh Totonchi, Mohammad Reza},
title = {Targeted Delivery of Medicinal Products in Advanced Therapy using Cellular Knowledge Seeding},
booktitle = {چهاردهمین کنگره بین المللی سلول های بنیادی رویان},
year = {2018},
location = {تهران, IRAN},
keywords = {Targeted Delivery; Advanced therapy medicinal products; Knowledge Seeding; Artificial Intelligence.},
}

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%0 Conference Proceedings
%T Targeted Delivery of Medicinal Products in Advanced Therapy using Cellular Knowledge Seeding
%A ,
%A Akbarzadeh Totonchi, Mohammad Reza
%J چهاردهمین کنگره بین المللی سلول های بنیادی رویان
%D 2018

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