Background and Aim:Background: Escherichia coli E. coli( is the most common causative agent of urinary tract infection (UTI). The UTI caused by antibiotic-resistant isolates are increasing. The type of selected antibiotics for the experimental treatment of UTI is currently under discussion. By now, 20 to 50 percent of the strains of E. coli have been resistant to first-line antibiotics, even in developed countries. The aim of this study was to determine the pattern of antibiotic resistance in E.coli isolates from patients with urinary tract infection in Mashhad. Methods:Methods: In this study, 60 strains of E. coli isolated from urine specimens were studied in Imam Reza Hospital in 1395 and 1396. After biochemical tests, antibiogram test were performed using Kirby-Bauer method. Results:Results: Of the 60 isolates of E. coli, 55% of women and 45% of men had urinary tract infections. Based on the results, the lowest resistance to Amikacin was 3.3%, Nitrofurantoin 10%, Imipenem and Meropenem 11.6%, Gentamicin 20%, and the highest resistance was to Ampicillin 86.6%. Resistance in the cephalosporin family was Cefotaxime 71.7%, Cefazolin 61.7%, ceftriaxone 60%, Cefixime 55.6%, Cefepime 46.7%, and Ceftazidime 45%, respectively. Among the quinolones, Ciprofloxacin was 58.3% and Nalidixic acid was 48.3% resistant. Conclusion:Conclusion: In the treatment of urinary tract infections, antibiotic therapy is experimental and accurate information on the susceptibility of bacteria in the area can be useful for achieving the best treatment.

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