Asymmetric Mannich and Mannich-type reactions are important carbon-carbon bond- -amino carbonyl derivatives.[1] -lactam and - -amino acid derivatives, peroxy acetylenic alcohols/ethers, and medicinally important materials. Several strategies[2,3] are -amino carbonyl compounds, including organocatalysis transition-metal catalysis, Bronsted and Lewis acid catalysis, phasetransfer catalysis, biocatalysis and ionic-liquid catalysis. Herein we report a highly anti-diastereoselective three-component Mannich reaction of aromatic amines and aldehydes with cyclohexanone in water as solvent and efficient nano organocatalyst. Reusability, easy workup, inexpensive, ready availability, short reaction time and its high diastereoselctivity 70-100% makes this catalyst an attractive alternative to the existing catalyst -amino carbonyls.

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