Abstract Introduction: Studies are increasing about elderly people’s health. The reason of this enhanced studies are the increasing number of elderly people in developed countries, therapeutic budget using for health of this population and the human tendency to extend the life time and quality. One of the main theories which mostly accepted is the oxidative stress theory. So, the aim of this study was to investigate the effect of eight weeks of aerobic training and training in water on DNA oxidative damage in elderly women. Method: Hence, 45 volunteered women participate as a subject for the study. Subjects were randomly divided into three groups; 1) Aerobic (15 subjects), 2) Training in water (15 subjects) and 3) Control (15 subjects). Before the beginning of the training period, 8-OHdG amounts measured. Both training groups were performed aerobic exercise on lane and water for three sessions per week with 65-75 percent of maximum heart rate. At the end of the training period, again, the blood sampling were repeated. For the statical analysis, ANOVA test was used, and for significant variables Bunferroni post hoc was used. Results: Results showed significant difference in the level of OHdG between trained groups and the control group after the raining period (p <0.004). There were no significant difference between training groups (p <0.734). Conclusion: In general, the results showed that moderate aerobic exercise in water and land can decrease oxidative stress induced damage and increase antioxidant system capacity.

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