In order to estimate of optimized application rates of water superabsorbent, humic acid and irrigation in cultivation of maize (Zea mays L.), an experiment as Box Behnken design using Response Surface Methodology, was conducted at Research Farm of Ferdowsi University of Mashhad, during 2013-14 growing season. The experimental treatments were designed considering of the high and the low levels of water superabsorbent (80 and 160 kg.ha-1), humic acid (4 and 8 kg.ha-1) and irrigation (200 and 400 m3.ha-1) using MINITAB 17 statistical software, as the central point in every treatment replicated 3 times, so 15 treatment combinations were provided totally. The result showed that linear effects of humic acid and irrigation and quadratic effects of superabsorbent an d irrigation were significant on seed yield. In eco-environmental scenario, using 123.63 kg.ha-1 superabsorbent, 7.19 kg.ha-1 humic acid and 323.23 m3.ha-1 irrigation, resulted in the highest seed yield (26309 kg.ha-1) and the highest water use efficiency (5.23). According to the ecological perspective, eco-environmental scenario is a priority compared two other scenarios, therefore by using the optimized values of resources in this scenario can be achieved to the sustainable production of maize, meanwhile can be minimized environmental pollutions. 

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