2nd International and 10th National Iranian Neurogenetic Congress , 2018-02-21

Title : ( Genetic basis of Autism a neurogenetic complex disease )

Authors: Zeinab Neshati ,

Access to full-text not allowed by authors

Citation: BibTeX | EndNote

Abstract

Autism spectrum disorder (ASD) is a neurogenetic syndrome which the majority of its pre-symptomatic behavioral markers are investigated in the first year of life. The neural systems associated with these behaviors, include the precuneus, the posterior cingulate cortex, the intraparietal sulcus, the corpus callosum and the cerebellum. Several genetically defined autism syndromes (16p11 deletion, PTEN and CHD8 mutations) are associated with increased numbers of pre-frontal cortical neurons and macrocephaly. CHD8 is shown to control expression of other ASD risk genes such as DYRK1A, GRIN2B and POGZ. Mutation of DYRK1A is strongly linked with seizures at infancy, hypertonia, intellectual disability, microcephaly, dysmorphic facial features and impaired speech. POGZ gene which progress cell cycle, contributes to vision problems, motor coordination impairment, microcephaly, hyperactivity and feeding problems. Around 70% of ASD patients share aberrant acetylome signature which is associated with synaptic transmission, ion transport, epilepsy, behavioral abnormality, chemokinesis, histone deacetylation and immunity. Differential methylation of CpG loci in three brain regions: temporal cortex, dorsolateral prefrontal cortex and cerebellum and differential methylation of some genes (PRRT1, C11orf21/TSPAN32, ZFP57, SHANK3 and SDHAP3) have been detected in ASD. There is also a significant association between ASD and a single nucleotide polymorphism that resides in a noncoding RNA that is an antisense inhibitor of the gene for moesin, a protein that regulates neuronal architecture. Finally, identification of genetic basis of ASD can be beneficial for discovery of therapeutic approaches. Some of the ASD-related genes can be targeted by pharmaceutical intervention and there are 7 genes for which specific drugs-gene interactions have been known. Investigation of the prevalent causes of ASD would be promising in therapeutic perspectives.

Keywords

, Autism, Genetic basis, Symptomatic behaviors, Therapeutic intervention.
برای دانلود از شناسه و رمز عبور پرتال پویا استفاده کنید.

@inproceedings{paperid:1072083,
author = {Neshati, Zeinab},
title = {Genetic basis of Autism a neurogenetic complex disease},
booktitle = {2nd International and 10th National Iranian Neurogenetic Congress},
year = {2018},
location = {IRAN},
keywords = {Autism; Genetic basis; Symptomatic behaviors; Therapeutic intervention.},
}

[Download]

%0 Conference Proceedings
%T Genetic basis of Autism a neurogenetic complex disease
%A Neshati, Zeinab
%J 2nd International and 10th National Iranian Neurogenetic Congress
%D 2018

[Download]