Bisphenol A is an important endocrine distruptor and leads to a considerable risk on human health and ecosystem[1]. Because of its widespread use in industrial and household applications, it has become a worldwide concern in recent decades[2]. Therefore, development of reliable analytical methods for detection of trace levels of Bisphenol A in different matrices is of critical importance. Herein, a disposable electrochemical sensor constructed from a gold DVD -GDVD- platform crowned with gold nanoparticles@β-cyclodextrin@nanodiamond is proposed for detection of Bisphenol A. The electrode is prepared in five successive steps. First, a silver nanofilm is electrodeposited on the GDVD platform. Then, the silver film is replaced galvanically with gold and selective etching of silver is carried out by nitric acid and ammonia to obtain a nanoporous gold film. Thereafter, β-cyclodextrin stabilized gold nanoparticles and an aqueous nanodiamond dispersion are drop casted at the as-prepared platform, respectively. The characterization of the electrode surface at each stage was performed using scanning electron microscopy and atomic force microscopy. Also, β-cyclodextrin stabilized gold nanoparticles was characterized using UV-Vis spectrophotometry, transmission electron microscopy, and dynamic light scattering. Electrochemical oxidation behavior of bisphenol A at the surface of the modified electrode was investigated using cyclic voltammetry which showed an irreversible oxidative wave with decreased oxidation overpotential and increased current response compared to the bare GDVD electrode. Linear sweep voltammetry was used for quantitative measurements after careful optimization of influential operating conditions. The reproducibility of the method defined as RSD% was obtained to be 4.01%. The analytical applicability of the proposed sensor was demonstrated by determination of bisphenol A in water and beverages. The cheap disposable GDVD platforms removes the concerns about the memory effects and tedious solid surface polishing.

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