Microchemical Journal, ( ISI ), Volume (146), No (1), Year (2019-5) , Pages (1054-1063)

Title : ( A new electrochemical aptasensor based on MWCNT-SiO2@Au core-shell nanocomposite for ultrasensitive detection of bisphenol A )

Authors: Iman Razavipanah , Glamhossein Ronagi , behjat deiminiat , Saeed Damirchi , خلیل آبنوس , Mohammad Izadyar , Mohammad Khavani Sariani ,

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Abstract

Detection and quantitation of bisphenol A -BPA- level in food samples and environment are of great signifcance. In this research work, a new electrochemical aptasensor was developed for ultrasensitive detection of BPA, based on MWCNT/SiO2@Au nanocomposite. Molecular dynamic -MD- simulation was carried out in order to better understand the interaction between the target molecules and the aptamer from molecular point of view. The detection strategy of the proposed electrochemical aptasensor, is based on [Fe -CN-6]3-/4- as a label free redox probe. In the absence of BPA molecules, the aptamers remain unfold so that the long tunnels for receiving the [Fe-CN-6]3-/4- redox probe are formed at the surface of the electrode. But, upon addition of BPA molecules, strong interactions between the BPA molecules and the aptamer are occurred. Therefore, the entrance of the tunnels is closed which results in a hard electron exchange between the redox probe and the electrode surface. Therefore, the electrochemical signal is decreased in the presence of BPA molecules. The proposed electrochemical aptasensor shows a high selectivity toward BPA molecules with a limit of detection -LOD- as low as 10 pM. The fabricated electrochemical aptasensor was successfully applied for detection of BPA in food samples.

Keywords

, Electrochemical aptasensor Bisphenol A Core, shell nanocomposite Molecular dynamic simulation
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@article{paperid:1073339,
author = {Razavipanah, Iman and Ronagi, Glamhossein and Deiminiat, Behjat and Damirchi, Saeed and خلیل آبنوس and Izadyar, Mohammad and Khavani Sariani, Mohammad},
title = {A new electrochemical aptasensor based on MWCNT-SiO2@Au core-shell nanocomposite for ultrasensitive detection of bisphenol A},
journal = {Microchemical Journal},
year = {2019},
volume = {146},
number = {1},
month = {May},
issn = {0026-265X},
pages = {1054--1063},
numpages = {9},
keywords = {Electrochemical aptasensor Bisphenol A Core-shell nanocomposite Molecular dynamic simulation},
}

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%0 Journal Article
%T A new electrochemical aptasensor based on MWCNT-SiO2@Au core-shell nanocomposite for ultrasensitive detection of bisphenol A
%A Razavipanah, Iman
%A Ronagi, Glamhossein
%A Deiminiat, Behjat
%A Damirchi, Saeed
%A خلیل آبنوس
%A Izadyar, Mohammad
%A Khavani Sariani, Mohammad
%J Microchemical Journal
%@ 0026-265X
%D 2019

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