4th International Student Biotechnology Congress , 2019-02-25
Title : ( Preparation and Evaluation of Polyethylenimine Coated Cerium Oxide Nanoparticles as a Novel Gene Delivery Vector )
Authors: Leila Hasanzadeh , Majid Daroudi , Navid Ramezanian , Reza Kazemi Oskuie ,
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Abstract
Cerium oxide nanoparticles have pH-dependent antioxidant activity. CeO2-NPs provide protection normal cells from various forms of reactive oxygen species (ROS), but possess innate cytotoxicity and apoptosis to cancer cells. To expand the applications of CeO2-NPs and improve gene delivery efficiency and reduce cytotoxicity of Polyethylenimine (PEI), the purpose of this study is design a PEI coated CeO2-NPs as a novel gene delivery vector with high transfection efficiency and low cytotoxicity.
