ChemistrySelect, Volume (4), No (31), Year (2019-8) , Pages (8930-8933)

Title : ( Synthesis and Antibacterial Evaluation of New Pyrimidyl N‐Ciprofloxacin Derivatives )

Authors: majid mokaber , Hossein Eshghi , marzieh akbarzadeh , Mostafa Gholizadeh , Yahya Mirzaie , Mohammad Hakimi , Jalil Lari ,

Access to full-text not allowed by authors

Citation: BibTeX | EndNote


Herein, nucleophilic substitution reaction of pyrimidine derivatives on piperazine in ciprofloxacin resulted in the formation of new pyrimidyl N-ciprofloxacines. These compounds were prepared at room temperature, at conventional heating and under microwave irradiation conditions. Results indicated microwave condition as a green approach in comparison with room temperature and at conventional heating condition leads to higher yields and very short reaction times. 1H, 13C-NMR, FTIR, Mass spectroscopy and CHN analysis were used to characterize all the synthesized products. Meanwhile, the antibacterial activity of these new compounds against gram-positive and gram-negative bacteria was investigated and showed more activities for two new N-ciprofloxacin derivatives than ciprofloxacin.


Antibiotics · Ciprofloxacin · Fluoroquinolones · Heterocycles · Microwave chemistry
برای دانلود از شناسه و رمز عبور پرتال پویا استفاده کنید.

author = {Mokaber, Majid and Eshghi, Hossein and Akbarzadeh, Marzieh and Gholizadeh, Mostafa and یحیی میزایی and محمد حکیمی and جلیل لاری},
title = {Synthesis and Antibacterial Evaluation of New Pyrimidyl N‐Ciprofloxacin Derivatives},
journal = {ChemistrySelect},
year = {2019},
volume = {4},
number = {31},
month = {August},
issn = {2365-6549},
pages = {8930--8933},
numpages = {3},
keywords = {Antibiotics · Ciprofloxacin · Fluoroquinolones · Heterocycles · Microwave chemistry},


%0 Journal Article
%T Synthesis and Antibacterial Evaluation of New Pyrimidyl N‐Ciprofloxacin Derivatives
%A Mokaber, Majid
%A Eshghi, Hossein
%A Akbarzadeh, Marzieh
%A Gholizadeh, Mostafa
%A یحیی میزایی
%A محمد حکیمی
%A جلیل لاری
%J ChemistrySelect
%@ 2365-6549
%D 2019