The 27th Iranian Conference of Organic Chemistry , 2019-08-21

Title : ( A straightforward approach for the synthesis of diverse derivatives of a novel selenium containing heterocyclic system [1,3]selenazolo[4,5-d]pyrimidine-5(4H)-thione using phenyl isothiocyanates )

Authors: Seddigheh Sheikhi-Mohammareh , Ali Shiri ,

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Abstract

In the recent years, selenazoles have been reported to have very unique chemical and biological properties such as inactivation of free radicals,1 antioxidant,2 cancer cell proliferation 3 and protein kinase activation 4. In view of the importance of these heterocyclic cores, many synthetic methodologies have been reported in the literature 5. Herein, we wish to report a one-pot procedure for the synthesis of various derivatives of [1,3]selenazolo[4,5-d]pyrimidine-5(4H)-thione as a novel selenium containing heterocyclic system. These potential pharmacologically active derivatives 3 (a-i) were synthesized via heterocyclization of 4-amino-2-(sec-amin substituted)-5-carbonitrile-1,3-selenazoles 1 (a-c) with various phenyl isothiocyanates 2 (a-c) in the presence of pyridine in excellent yields. The structural assignments of all the newly synthesized compounds are based upon spectroscopic and microanalytical data.

Keywords

, Selenazoles, Phenyl isothiocyanates, One-pot procedure, Selenium containing heterocyclic system
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@inproceedings{paperid:1075545,
author = {Sheikhi-Mohammareh, Seddigheh and Shiri, Ali},
title = {A straightforward approach for the synthesis of diverse derivatives of a novel selenium containing heterocyclic system [1,3]selenazolo[4,5-d]pyrimidine-5(4H)-thione using phenyl isothiocyanates},
booktitle = {The 27th Iranian Conference of Organic Chemistry},
year = {2019},
location = {ارومیه, IRAN},
keywords = {Selenazoles; Phenyl isothiocyanates; One-pot procedure; Selenium containing heterocyclic system},
}

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%0 Conference Proceedings
%T A straightforward approach for the synthesis of diverse derivatives of a novel selenium containing heterocyclic system [1,3]selenazolo[4,5-d]pyrimidine-5(4H)-thione using phenyl isothiocyanates
%A Sheikhi-Mohammareh, Seddigheh
%A Shiri, Ali
%J The 27th Iranian Conference of Organic Chemistry
%D 2019

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