Title : ( Viability assessment of esophageal squamous cell carcinoma cells upon co-administration of ellagic acid derivatives and radiation )
Authors: sara mirzaei safiabad , Maryam Moghaddam Matin , Fatemeh Behnam Rassouli , Milad Iranshahy , Hamid Gholamhosseinian ,
Full TextAbstract
Introduction: Current therapeutic approachesfor esophageal cancer are chemical drugsand radiotherapy, however, rate of morbidity and mortality of this malignancy is growing. The purposeof present study was to determine whether ellagic acid derivatives could enhanceefficacy of radiotherapyin esophageal cancercells. Methods: To do so, KYSE30 cells were treated with 20 μM of urolithin a (UA), urolithin b (UB) and methylated UA (mUA) for 24, 48, 72and 96 h. Then, radiation was applied in different doses, 2, 4 and 6 Gry, and viability of cells was assed48 h after combinatorial treatments. Results: MTT results revealedthat UA increased toxicity of 2 Gry radiation up to 67.02%. Moreover, pretreatment of cells with mUA increased toxicity of 6 Gry radiation by 11.2%.In addition, calculated increased toxicity of 4 Gry radiation by UA was 7.00%Conclusion: In order to enhance efficacy of radiation in esophageal cancer cells, weevaluated effects of ellagic acid derivatives in combination with radiotherapy. Our findings revealed increased toxicity of 2, 4 and 6 Gry radiation by UA and mUA.
Keywords
, Esophageal carcinoma, Ellagic acid derivatives, Radiation, Cellviability
@inproceedings{paperid:1075784,
author = {Mirzaei Safiabad, Sara and Moghaddam Matin, Maryam and Behnam Rassouli, Fatemeh and میلاد ایرانشاهی and حمید غلامحسینیان},
title = {Viability assessment of esophageal squamous cell carcinoma cells upon co-administration of ellagic acid derivatives and radiation},
booktitle = {3rd International and 11th National Biotechnology Congress of Islamic Republic of Iran},
year = {2019},
location = {تهران, IRAN},
keywords = {Esophageal carcinoma; Ellagic acid derivatives; Radiation; Cellviability},
}
%0 Conference Proceedings
%T Viability assessment of esophageal squamous cell carcinoma cells upon co-administration of ellagic acid derivatives and radiation
%A Mirzaei Safiabad, Sara
%A Moghaddam Matin, Maryam
%A Behnam Rassouli, Fatemeh
%A میلاد ایرانشاهی
%A حمید غلامحسینیان
%J 3rd International and 11th National Biotechnology Congress of Islamic Republic of Iran
%D 2019
