3rd International and 11th National Biotechnology Congress of Islamic Republic of Iran , 2019-09-01

Title : ( Investigating anti-cancer effects of 6-geranyloxycarbostyril on prostate cancer cells )

Authors: mehrdad aghasizadeh sharbaf , Ahmad Reza Bahrami , Hamid Sadeghian , Maryam Moghaddam Matin ,

Citation: BibTeX | EndNote

Abstract

Prostate cancer is one of the most common cancers in the world, which is dependent on age and sex. Prostate cancer incidence increases with age in men and, if not diagnosed and treated in timecan lead to death. Carbostyriles are composed of a large group of quinolone derivatives that contain a dissimilar 2-ring structure. Due to anti-cancer properties of carbostyril, the structure of this molecule is used as the basis for designing and discovery of novel anti-cancer drugs. In this study, anti-cancer effects of 6-geranyloxycarbostyril on PC3 and DU145 (prostate cancer cell lines) and also HDF (human dermal fibroblast cells) were evaluated by MTT assay. The result of MTT assay indicated that the IC50 values of this compound on PC3 and DU145 cells after 24, 48 and 72 hours were 43, 22 and 20 μg /ml, and 56, 35 and 51 μg /ml after 24,48 and 72 h, respectively. for HDF cells, the IC50 values were determined to be 218, 266, and 170μl /ml, respectively. Apoptosis inducing effects of 6-gq is an advantage of this agent compared to necrotic drugs. The mechanism of cell death induced by 6-gq was further investigated using PI-Annexin V double staning. Results of flowcytometry indicated that 6-gq could induced cell death in prostate cancer cells via apoptosis.Finally, our results demonstrate that 6-gq can be introduced as a potent anti-cancer agents. Research in animal models can be considered in later studies.

Keywords

, prostate cancer, carbostyril, cell cytotoxicity, apoptosis, HDF
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@inproceedings{paperid:1075793,
author = {Aghasizadeh Sharbaf, Mehrdad and Bahrami, Ahmad Reza and حمید صادقیان and Moghaddam Matin, Maryam},
title = {Investigating anti-cancer effects of 6-geranyloxycarbostyril on prostate cancer cells},
booktitle = {3rd International and 11th National Biotechnology Congress of Islamic Republic of Iran},
year = {2019},
location = {تهران, IRAN},
keywords = {prostate cancer; carbostyril; cell cytotoxicity; apoptosis; HDF},
}

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%0 Conference Proceedings
%T Investigating anti-cancer effects of 6-geranyloxycarbostyril on prostate cancer cells
%A Aghasizadeh Sharbaf, Mehrdad
%A Bahrami, Ahmad Reza
%A حمید صادقیان
%A Moghaddam Matin, Maryam
%J 3rd International and 11th National Biotechnology Congress of Islamic Republic of Iran
%D 2019

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