Colorectal cancer (CRC) is one of the most common cancers worldwide. Despite significant progress has made in diagnosis and treatment strategies, CRC is still the 2nd major cause of cancer related deaths in the world. In the last decades, natural products have received attention for discovery of novel anticancer therapeutic agents. Baicalin, a flavonoid found in Scutellaria baicalensis, has been regarded as a potent anticancer agent. In this study, cytotoxic effects of baicalin on mouse C26 and CT26 CRC cells was examined by MTT assay. Baicalin showed antiproliferative effects in C26 and CT26 cells with IC50 values of 82.04 µM and 44.68 µM, respectively. These results suggest that baicalin has potent anticancer effects against colorectal cancer cells and could be considered as a potential and effective drug for cancer therapy

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