بیست و هفتمین سمینار شیمی آلی ایران , 2019-08-21

Title : ( Synthesis and characterization of novel 4-(1-(pyrimidin-4-yl)ethyl)-12H-pyrimido[4\\\',5\\\':5,6][1,4]thiazino[2,3-b]quinoxaline derivatives )

Authors: Toktam Afrough , Mehdi Bakavoli , Hossein Eshghi ,

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Abstract

Development of straightforward and efficient methods for rapid construction of nitrogen and sulfur-containing heterocyclic compounds is an important target in synthetic, medicinal chemistry and in drug design.1 For instance, heterocycles containing a 1,4-thiazine moiety as a class of pharmaceutically important compounds exhibit various pharmaceutical activities including antibacterial, antiprolifrative, anticancer, antiepileptic, anthelmintic, antihypertensive, antiviral, antifungal, antiinflammatory, antimalaria, and antithyroid. The first attempt to synthesize 1,4-thiazines was made by Charles Barkenbus in 1948.2 Subsequently, other methods for the synthesis of 1,4-thiazine derivatives and heterocycles containing a 1,4-thiazine moiety have been reported in the literature.1,3 Herein, we report an efficient one-pot synthetic approach to the synthesis of new 4-(1-(pyrimidin-4-yl)ethyl)-12H-pyrimido[4\\\',5\\\':5,6][1,4]thiazino[2,3-b]quinoxaline derivatives from 5-bromo-4-[1-(5-bromo- 2,6-dichloropyrimidin-4-yl)ethyl]-2-chloro-6-methylpyrimidine 2 obtained from compound 14 and 3-aminoquinoxaline-2-thiol 3 under mild conditions at room temperature.

Keywords

, Pyrimido[4\\\', 5\\\':5, 6][1, 4]thiazino[2, 3-b]quinoxaline, Condensation reaction.
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@inproceedings{paperid:1076070,
author = {Afrough, Toktam and Bakavoli, Mehdi and Eshghi, Hossein},
title = {Synthesis and characterization of novel 4-(1-(pyrimidin-4-yl)ethyl)-12H-pyrimido[4\\\',5\\\':5,6][1,4]thiazino[2,3-b]quinoxaline derivatives},
booktitle = {بیست و هفتمین سمینار شیمی آلی ایران},
year = {2019},
location = {ارومیه, IRAN},
keywords = {Pyrimido[4\\\';5\\\':5;6][1;4]thiazino[2;3-b]quinoxaline; Condensation reaction.},
}

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%0 Conference Proceedings
%T Synthesis and characterization of novel 4-(1-(pyrimidin-4-yl)ethyl)-12H-pyrimido[4\\\',5\\\':5,6][1,4]thiazino[2,3-b]quinoxaline derivatives
%A Afrough, Toktam
%A Bakavoli, Mehdi
%A Eshghi, Hossein
%J بیست و هفتمین سمینار شیمی آلی ایران
%D 2019

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