Journal of Maxillofacial and Oral Surgery, Volume (19), No (1), Year (2020-3) , Pages (85-92)

Title : ( Is Impregnation of Xenograft with Caffeine Effective on Bone Healing Rate in Mandibular Defects? A Pilot Histological Animal Study )

Authors: Sahand Samieirad , Vajiheh Mianbandi , Hamideh Salari Sedigh , Majid Hosseini-Abrishami , Farid Shiezadeh , Hossein Bagheri , Elahe Tohidi , Nasrollah Saghravanian ,

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Abstract

Introduction and Aim The aim of this study was to evaluate the effect of two concentrations of caffeine (1.5% and 3%) powder added to Bio-Oss xenograft on bone healing rate of iatrogenic mandibular defects in dogs. Materials and Method The researchers implemented a pilot study on ten male adult mongrel dogs. Two 4-mm circular critical-sized defects were trephined on each side of the mandibular body (a total of 4 defects for each dog). One of the defects remained empty as a control group. The other three defects in each case were randomly filled with 1.5% or 3% caffeinated Bio-Oss or pure Bio-Oss. The mandible specimens were sent for histological and histomorphometric assessments, 4 months postoperatively. Our predictor variable was the type of bone substitute. The study outcomes were new bone formation, angiogenesis, and fibrosis. The p value was set at 0.05 using SPSS 16. Results The histological assessment showed that the administration of 1.5% caffeinated Bio-Oss to mandibular defects caused more angiogenesis and more new bone formation as well as less fibrosis compared to the other groups (p<0.05). Conclusion This study suggested that the application of 1.5% caffeinated Bio-Oss in bone defects of dogs resulted in the higher new bone formation. However, further clinical trials are needed to support its relevancy.

Keywords

, Caffeine Bio, Oss Xenograft New bone formation
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@article{paperid:1076505,
author = {سهند سمیعی راد and Vajiheh Mianbandi and Salari Sedigh, Hamideh and مجید حسینی ابریشمی and فرید شیعه زاده and حسین باقری and الهه توحیدی and Nasrollah Saghravanian},
title = {Is Impregnation of Xenograft with Caffeine Effective on Bone Healing Rate in Mandibular Defects? A Pilot Histological Animal Study},
journal = {Journal of Maxillofacial and Oral Surgery},
year = {2020},
volume = {19},
number = {1},
month = {March},
issn = {0972-8279},
pages = {85--92},
numpages = {7},
keywords = {Caffeine Bio-Oss Xenograft New bone formation},
}

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%0 Journal Article
%T Is Impregnation of Xenograft with Caffeine Effective on Bone Healing Rate in Mandibular Defects? A Pilot Histological Animal Study
%A سهند سمیعی راد
%A Vajiheh Mianbandi
%A Salari Sedigh, Hamideh
%A مجید حسینی ابریشمی
%A فرید شیعه زاده
%A حسین باقری
%A الهه توحیدی
%A Nasrollah Saghravanian
%J Journal of Maxillofacial and Oral Surgery
%@ 0972-8279
%D 2020

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