Journal of Cluster Science, ( ISI ), Volume (31), No (1), Year (2020-1) , Pages (1-10)

Title : ( A Nano-sized Nd–Ag@polyoxometalate Catalyst for Catalyzing the Multicomponent Hantzsch and Biginelli Reactions )

Authors: Manizheh Ghanbarian , Seyeed Yahya Shirazi Beheshtiha , Majid M. Heravi , Masoud Mirzaei Shahrabi , Vahideh Zadsirjan , Nahid Lotfian ,

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Abstract

For the first time the catalytic activity of AgNdSiW11, was examined in two named reactions, namely Hantzsch and Biginelli reactions. A simple, eco-friendly and highly efficient one-pot synthesis of polyhydroquinoline derivatives via Hantzsch multicomponent reactions (MCRs) involving cyclocondensation of differently-substituted aldehydes, β-ketoesters or dimedone, active methylene compounds, and ammonium acetate as a source of nitrogen, in the presence of AgNdSiW11 as a catalyst in EtOH/H2O under reflux conditions in high yields was successfully achieved. Furthermore, the catalytic performance of AgNdSiW11 was also successfully tested in the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones via Biginelli MCR involving cyclocondensation of differently-substituted aldehydes, ethyl acetoacetate and urea as source of nitrogen in the presence of AgNdSiW11 under reflux conditions in EtOH/H2O. This prolific combination of Ln and POMs inaugurates a powerful class of catalysts for the different chemical transformations, which overcomes key limitations of previously established salts and Lewis acidic metals-based catalysts under low catalyst loading, the use of water scavengers, dry solvents and additives for facilitating the specialized experimental setups commonly employed to the organic reactions.

Keywords

, Mono, lacunary Keggin; Multicomponent reaction; One, pot manner; Polyhydroquinolines; Hantzsch reaction; Dihydropyrimidones; Biginelli reaction.
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@article{paperid:1076956,
author = {Manizheh Ghanbarian and Seyeed Yahya Shirazi Beheshtiha and Majid M. Heravi and Mirzaei Shahrabi, Masoud and Vahideh Zadsirjan and Nahid Lotfian},
title = {A Nano-sized Nd–Ag@polyoxometalate Catalyst for Catalyzing the Multicomponent Hantzsch and Biginelli Reactions},
journal = {Journal of Cluster Science},
year = {2020},
volume = {31},
number = {1},
month = {January},
issn = {1040-7278},
pages = {1--10},
numpages = {9},
keywords = {Mono-lacunary Keggin; Multicomponent reaction; One-pot manner; Polyhydroquinolines; Hantzsch reaction; Dihydropyrimidones; Biginelli reaction.},
}

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%0 Journal Article
%T A Nano-sized Nd–Ag@polyoxometalate Catalyst for Catalyzing the Multicomponent Hantzsch and Biginelli Reactions
%A Manizheh Ghanbarian
%A Seyeed Yahya Shirazi Beheshtiha
%A Majid M. Heravi
%A Mirzaei Shahrabi, Masoud
%A Vahideh Zadsirjan
%A Nahid Lotfian
%J Journal of Cluster Science
%@ 1040-7278
%D 2020

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