Reaction Kinetics, Mechanisms and Catalysis, ( ISI ), Volume (129), No (1), Year (2020-3) , Pages (391-401)

Title : ( Chemoselective synthesis of drug-like pyrrolo[2,3,4-kl]acridin-1-one using Polyoxometalate@Lanthanoid catalyst )

Authors: Mansoureh Daraie , Nahid Lotfian , Majid M. Heravi , Masoud Mirzaei Shahrabi ,

Citation: BibTeX | EndNote

Abstract

The incorporation of polyoxometalates (POMs) or metal oxides into the metal-organic frameworks (MOFs) opens new research avenues for the synthesis of heterogeneous catalysts. In this project, a catalytic system based on Neodymium clusters and Keggin-type of heteropoly acid (HPA) (Na[Nd(pydc-OH)(H2O)4]3}[SiW12O40]) was used as heterogeneous catalyst for one pot synthesis of Pyrroloacridines, via multi component reactions involving dimedone, isatin and aniline in green condition. The novelty of this work originates from using inorganic-organic hybrids based upon polyoxometalates in catalyzing organic transformation. Compared with parent HPA (89.0% yield in 15 min for [SiW12O40]4−), this hybrid catalyst showed higher catalytic activity (94% yield in 8 min) in Pyrroloacridines synthesis. The hybrid compound could be reused at least five times without obvious loss of the catalytic activity.

Keywords

, Polyoxometalate; Pyrrolo[2, 3, 4-kl]acridin-1-ones; Inorganic-organic hybrid catalyst; Chemoselective synthesis; Green chemistry.
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@article{paperid:1077375,
author = {منصوره دارایی and ناهید لطفیان and مجید م هروی and Mirzaei Shahrabi, Masoud},
title = {Chemoselective synthesis of drug-like pyrrolo[2,3,4-kl]acridin-1-one using Polyoxometalate@Lanthanoid catalyst},
journal = {Reaction Kinetics, Mechanisms and Catalysis},
year = {2020},
volume = {129},
number = {1},
month = {March},
issn = {1878-5190},
pages = {391--401},
numpages = {10},
keywords = {Polyoxometalate; Pyrrolo[2;3;4-kl]acridin-1-ones; Inorganic-organic hybrid catalyst; Chemoselective synthesis; Green chemistry.},
}

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%0 Journal Article
%T Chemoselective synthesis of drug-like pyrrolo[2,3,4-kl]acridin-1-one using Polyoxometalate@Lanthanoid catalyst
%A منصوره دارایی
%A ناهید لطفیان
%A مجید م هروی
%A Mirzaei Shahrabi, Masoud
%J Reaction Kinetics, Mechanisms and Catalysis
%@ 1878-5190
%D 2020

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