تحقیقات دامپزشکی و فرآورده های بیولوژیک (دامپزشکی), دوره (33), شماره (1), سال (2019-12) , صفحات (47-53)

عنوان : ( Comparison of antimicrobial activity of thanatin peptide with two cinnamon and oregano essential oils on farm animal’s pathogenic bacterial isolates )

نویسندگان: علی جوادمنش , سیده زهرا موسوی , عباس تنهائیان , مرجان ازغندی ,

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چکیده

Unfortunately, using common antibiotics to treat animal infection is increasing in which leads to undesirable side effects such as antibiotic residuals in animal products and occurrence bacterial resistance to antibiotics. Therefore, researchers are searching for an alternative to traditional antibiotics with fewer side effects like herbal essential oils and antimicrobial peptides (AMPs) such as Oregano and Cinnamon essential oils as well as recombinant thanatin peptide. Minimum Inhibitory Concentrations (MIC) was used based on a microbroth dilution method by 96-well microtiter with four replicates with Oregano and Cinnamon essential oils as well as thanatin peptide. After MIC, bacteria species were cultured and minimum bactericidal concentration (MBC) was determined as that showing no growth. The results of MIC assay showed a strong activity against salmonella enteritidis bacteria with the value of MIC equal to 6 μg/ml by thanatin. Moreover, the lowest amount of MBC was observed on E. coli0157 and salmonella enteritidis approximately 25 μg/ml. Thanatin is one of the member of cationic AMPs that have received a great attention regarding growth inhibitory against wide range of microorganisms including Gram-negative and Gram-positive bacteria, as well as several fungi species. Thanatin showed a strong growth inhibitory against bacteria in compare with Oregano and Cinnamon essential oils. Thus, developing new antibiotics such as thanatin would be a great replacement for common antibiotics and may lead to a great progress in eliminating livestock pathogens.

کلمات کلیدی

, Bacterial infection, Antimicrobial peptides, Antibiotic resistant, Essential oil
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@article{paperid:1077723,
author = {جوادمنش, علی and موسوی, سیده زهرا and تنهائیان, عباس and ازغندی, مرجان},
title = {Comparison of antimicrobial activity of thanatin peptide with two cinnamon and oregano essential oils on farm animal’s pathogenic bacterial isolates},
journal = {تحقیقات دامپزشکی و فرآورده های بیولوژیک (دامپزشکی)},
year = {2019},
volume = {33},
number = {1},
month = {December},
issn = {2423-5407},
pages = {47--53},
numpages = {6},
keywords = {Bacterial infection; Antimicrobial peptides; Antibiotic resistant; Essential oil},
}

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%0 Journal Article
%T Comparison of antimicrobial activity of thanatin peptide with two cinnamon and oregano essential oils on farm animal’s pathogenic bacterial isolates
%A جوادمنش, علی
%A موسوی, سیده زهرا
%A تنهائیان, عباس
%A ازغندی, مرجان
%J تحقیقات دامپزشکی و فرآورده های بیولوژیک (دامپزشکی)
%@ 2423-5407
%D 2019

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