Critical Reviews in Biochemistry and Molecular Biology, Volume (53), No (2), Year (2018-3) , Pages (130-156)

Title : ( Structural fingerprints, interactions, and signaling networks of RAS family proteins beyond RAS isoforms )

Authors: Saeideh Nakhaeirad , Fereshteh Haghighi , Parivash Nouri , Soheila Rezaei , Jana Lissy , Neda S. Kazemein Jasem , Radovan Dvorsky , Mohammad Reza Ahmadian ,

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Abstract

Among the signaling molecules indirectly linked to many different cell surface receptors, RAS proteins essentially respond to a diverse range of extracellular cues. They control activities of multiple signaling pathways and consequently a wide array of cellular processes, including survival, growth, adhesion, migration, and differentiation. Any dysregulation of these pathway leads, thus, to cancer, developmental disorders, metabolic, and cardiovascular diseases. The biochemistry of RAS family proteins has become multifaceted since the discovery of the first members, more than 40 years ago. Substantial knowledge has been attained about molecular mechanisms underlying post-translational modification, membrane localization, regulation, and signal transduction through diverse effector molecules. However, the increasing complexity of the underlying signaling mechanisms is considerable, in part due to multiple effector pathways, crosstalks between them and eventually feedback mechanisms. Here, we take a broad view of regulatory and signaling networks of all RAS family proteins that extends beyond RAS paralogs. As described in this review, a lot is known but a lot has to be discovered yet.

Keywords

Effectors; GAPs; GEFs; RAS; protein family; scaffold proteins; signal transduction
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@article{paperid:1077929,
author = {Nakhaeirad, Saeideh and فرشته حقیقی and پریوش نوری and سهیلا رضایی and Jana Lissy and Neda S. Kazemein Jasem and Radovan Dvorsky and محمد رضا احمدیان},
title = {Structural fingerprints, interactions, and signaling networks of RAS family proteins beyond RAS isoforms},
journal = {Critical Reviews in Biochemistry and Molecular Biology},
year = {2018},
volume = {53},
number = {2},
month = {March},
issn = {1040-9238},
pages = {130--156},
numpages = {26},
keywords = {Effectors; GAPs; GEFs; RAS; protein family; scaffold proteins; signal transduction},
}

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%0 Journal Article
%T Structural fingerprints, interactions, and signaling networks of RAS family proteins beyond RAS isoforms
%A Nakhaeirad, Saeideh
%A فرشته حقیقی
%A پریوش نوری
%A سهیلا رضایی
%A Jana Lissy
%A Neda S. Kazemein Jasem
%A Radovan Dvorsky
%A محمد رضا احمدیان
%J Critical Reviews in Biochemistry and Molecular Biology
%@ 1040-9238
%D 2018

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