Herein a rapid, efficient, facile and environmentally benign synthesis of 2,3-dihydroquinazolin-4(1H)-ones using SBA-16/ GPTMS-TSC-CuI (CuI anchored onto mesoporous SBA-16 functionalized by aminated 3-glycidyloxypropyltrimethoxysilane with thiosemicarbazid) is reported. The aforesaid mesostructured catalyst with a unique “super-cage” structure and narrow particle size distribution (3-7 nm) exhibited excellent catalytic activity in high yielding preparation of 2,3 dihydroquinazolin- 4(1H)-ones from the condensation of 2-aminobenzamide and an aldehyde in solvent-free conditions. Furthermore, SBA-16/ GPTMS-TSC-CuI as a heterogeneous catalyst was stable under reaction conditions and can be recycled at least five times without any loss of its catalytic efficiency.

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