Iranian Journal of Basic Medical Sciences, ( ISI ), Volume (23), No (1), Year (2020-1) , Pages (36-45)

Title : ( Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and mTOR expression as a novel component in a rat model of PCOS )

Authors: Faeze Fazel Torshizi , Mohammad Chamani , Hamid Reza Khodaei , Ali Asghar Sadeghi , Seyed Hossein Hejazi , Reza Majidzadeh Heravi ,

Citation: BibTeX | EndNote

Abstract

Objective(s): Zinc is an effective factor in the reproductive system. Insulin resistance (IR) is known as an important disorder in patients with polycystic ovary syndrome (PCOS). Mammalian target of rapamycin (mTOR), which controls key cell activities, in particular, is activated in disorders such as PCOS. The present study was conducted to observe the therapeutic effects of organic zinc on IR, mTOR gene expression, and pathogenesis of PCOS in a rat model induced-PCOS. Materials and Methods: Experimental treatments were performed on control and treated groups, consisting of healthy controls (Control, water, and standard feed intake and daily injection of sesame oil alone), Polycystic control (PCO, injection of 4 mg/kg estradiol valerate (EV) for four weeks). Treated groups (PCO-ZM 25, PCO-ZM 75, and PCO-ZM 175) after 4 weeks of receiving EV, were daily given three levels of 25, 75, and 175 mg zinc methionine/kg BW for 15 days, respectively. Results: Injection of EV dramatically increased body and ovarian weights, levels of LH, testosterone, estradiol, triglyceride, fasting insulin, fasting glucose, HOMA-IR, IGF-1, gene expression of mTOR, and number of cysts (P<0.05). It also reduced the level of progesterone, HDL-C, and the number of antral follicles (P<0.05). However, by increasing zinc-methionine application especially at 175 mg/kg BW, the induction effects of EV were improved on ovarian cysts (P<0.05). Conclusion: Organic zinc showed beneficial effects in the EV induced PCOS rats via decreased insulin resistance and mTOR expression, restored the hormonal profile, and decreased the number of cysts in the ovaries.

Keywords

, Insulin resistance mTOR, Polycystic ovary syndrome, Rat Zinc-methionine
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@article{paperid:1079134,
author = {فائزه فاضل ترشیزی and محمد چمنی and حمیدرضا خدایی and علی اصغر صادقی and سید حسین هجازی and Majidzadeh Heravi, Reza},
title = {Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and mTOR expression as a novel component in a rat model of PCOS},
journal = {Iranian Journal of Basic Medical Sciences},
year = {2020},
volume = {23},
number = {1},
month = {January},
issn = {2008-3866},
pages = {36--45},
numpages = {9},
keywords = {Insulin resistance mTOR; Polycystic ovary syndrome;Rat Zinc-methionine},
}

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%0 Journal Article
%T Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and mTOR expression as a novel component in a rat model of PCOS
%A فائزه فاضل ترشیزی
%A محمد چمنی
%A حمیدرضا خدایی
%A علی اصغر صادقی
%A سید حسین هجازی
%A Majidzadeh Heravi, Reza
%J Iranian Journal of Basic Medical Sciences
%@ 2008-3866
%D 2020

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