Chlamydophila abortus (C. abortus) is a member of the Chlamydia family, which is the most common known infectious agent for enzootic abortion. It is a gram-negative intracellular bacteria responsible for major economic losses due to infection and subsequent induction of abortion in several animal species and public health problem in human beings. This study was conducted to determine the prevalence of antibody against C. abortus in sheep and goat populations of Khorasan Razavi province located in the north-east of Iran. Four hundred fifty-two (271 sheep and 181 goats) sample from 40 sheep/goat epidemiologic unit located in 11 counties were selected using multi-stage cluster random sampling. Sera were assayed for antibody against C. abortus using ID-VET ELISA kit. Of the 452 sheep and goat sera, 44 were positive for C. abortus antibodies. Seroprevalence of C. abortus at animal level was 9.7% (95%CI:7.1%-12.4%). In 28 out of 40 epidemiologic unit (70%) and 10 out of 11 counties (91%), at least one seropositive sample was found. There was no significant difference between the seropositivity of sheep and goat (p=0.471). Independent variables including age, sex, and location were included in the multivariate logistic regression model. None of the independent variables showed significant correlation with the serum test result in sheep and goats (p>0.05). Although seroprevalence of Antibody against C. abortus was not high in the study area, it was widespread. Considering the economic and public health importance of C. abortus in animals and humans, measures are to be implemented to prevent its spreading and to reduce the zoonotic risk of C. abortus in the studied region.

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