Journal of Biomolecular Structure and Dynamics, ( ISI ), Year (2020-6)

Title : ( Five new complexes with deferiprone and N,N-donor ligands: evaluation of cytotoxicity against breast cancer MCF-7 cell line and HSA-binding determination )

Authors: fatemeh delavar mendi , Amir SHokooh Saljooghi , Mohammad Ramezani , Rafal Kruszynski , Morgane Poupon , Monika Kucerakova , Volker Huch , Pawel Socha , Maryam Babaei , Mona Alibolandi ,

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Abstract

In this study, five new complexes containing deferiprone (dfp) and N,N-donor ligands [bipyridine (bpy), 1,10-phenanthroline (phen) and ethylenediamine (en)] were synthesized: [Fe(dfp)2(bpy)](PF6) (1), [Fe(dfp)2(phen)](PF6) (2), [Cu2(dfp)2(bpy)2](PF6)2 (3), [Ga(dfp)2(bpy)](PF6) (4), and [Fe(dfp)2(en)](PF6) (5). Characterization of these complexes was carried out through elemental analysis and FT-IR, and singlecrystal X-ray crystallography was used to determine their structures. Whilst the polyhedron has a distorted octahedral geometry in 1, 2, 4, and 5, it adopts a distorted square-pyramidal geometry in 3. Interaction of these compounds with human serum albumin (HSA) has been investigated through electronic absorption and fluorescence titration techniques. Emission quenching was performed separately for each complex at three different temperatures and thermodynamic parameters were calculated using binding constants to better understand the power of different binding forces with the HSA. Results demonstrated that compounds interact strongly with the HSA with a static quenching mechanism. Our evaluation of the cytotoxicity of complexes against the breast cancer MCF-7 cell line showed that complex 2 presents a better cytotoxicity than the standard cis-Pt. Finally, using the AutoDock 4.2 program, simulations to analyze the mechanism of complex–HSA interactions and their binding mode were carried out. Results showed that the best binding mode is located in subdomain IB for 1, 2, and 4, in I/II for 3, and in IA/IIA for 5.

Keywords

, Coordination compounds; deferiprone; human serum albumin; breast cancer; MCF, 7 cells
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@article{paperid:1080195,
author = {Delavar Mendi, Fatemeh and SHokooh Saljooghi, Amir and محمد رمضانی and رافائل کروزینسکی and مورگانه پوپان and مونیکا کوسراکف and ولکر هاچ and پاول سوشا and مریم بابایی and مونا علی بلندی},
title = {Five new complexes with deferiprone and N,N-donor ligands: evaluation of cytotoxicity against breast cancer MCF-7 cell line and HSA-binding determination},
journal = {Journal of Biomolecular Structure and Dynamics},
year = {2020},
month = {June},
issn = {0739-1102},
keywords = {Coordination compounds; deferiprone; human serum albumin; breast cancer; MCF-7 cells},
}

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%0 Journal Article
%T Five new complexes with deferiprone and N,N-donor ligands: evaluation of cytotoxicity against breast cancer MCF-7 cell line and HSA-binding determination
%A Delavar Mendi, Fatemeh
%A SHokooh Saljooghi, Amir
%A محمد رمضانی
%A رافائل کروزینسکی
%A مورگانه پوپان
%A مونیکا کوسراکف
%A ولکر هاچ
%A پاول سوشا
%A مریم بابایی
%A مونا علی بلندی
%J Journal of Biomolecular Structure and Dynamics
%@ 0739-1102
%D 2020

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