Title : ( One-pot, catalyst-free synthesis of novel spiro[indole-3,4′-pyrano[2′,3′:4,5]pyrimido [2,1-b][1,3]benzothiazole] derivatives )
Authors: mahdie zangouei , Abbas Ali Esmaeili ,
Full TextAbstract
The present report describes one-pot three-component condensation of isatins, malononitrile, and 2-hydroxy-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one in water–ethanol mixture at reflux to develop an efficient one-pot protocol for the synthesis of novel spiro[indole-3,4′-pyrano[2′,3′:4,5]pyrimido[2,1-b][1,3]benzothiazole] derivatives. The significant features of this protocol are short reaction times, avoidance of toxic catalysts, and provision of excellent yields, no column chromatographic purification, and use of ethanol-water as an environmentally benign solvent. The molecular structure of 4a has been supported by single-crystal X-ray diffraction.
Keywords
, 2-hydroxy-4H-pyrimido[2, 1-b][1, 3]benzothiazol-4-one, isatin, malononitrile, multicomponent reactions, spirooxindole
@article{paperid:1080969,
author = {Zangouei, Mahdie and Esmaeili, Abbas Ali},
title = {One-pot, catalyst-free synthesis of novel spiro[indole-3,4′-pyrano[2′,3′:4,5]pyrimido [2,1-b][1,3]benzothiazole] derivatives},
journal = {Journal of Chemical Research},
year = {2020},
volume = {44},
month = {April},
issn = {1747-5198},
pages = {646--652},
numpages = {6},
keywords = {2-hydroxy-4H-pyrimido[2;1-b][1;3]benzothiazol-4-one; isatin; malononitrile; multicomponent reactions; spirooxindole},
}
%0 Journal Article
%T One-pot, catalyst-free synthesis of novel spiro[indole-3,4′-pyrano[2′,3′:4,5]pyrimido [2,1-b][1,3]benzothiazole] derivatives
%A Zangouei, Mahdie
%A Esmaeili, Abbas Ali
%J Journal of Chemical Research
%@ 1747-5198
%D 2020
