Cell and Tissue Banking, ( ISI ), Year (2020-6)

Title : ( Protective effects of acetyl-l-carnitine against serum and glucose deprivation-induced apoptosis in rat adipose-derived mesenchymal stem cells )

Authors: Arash Abdolmaleki , Mohammad Bagher Ghayour , Morteza Behnam Rassouli ,

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Abstract

Low survival rate of grafted mesenchymal stem cells (MSC) in injured tissue is one of the major limitations of stem cell therapy. One of the most important factors that limits the MSCs survival rate and retention is ischemic stress, which can lead to damage to all components of the cell. In particular, it can damage mitochondria, that play an important role in apoptosis with releasing apoptotic factors. Therefore, we investigated the protective effects of Acetyl- L-carnitine (ALCAR) against serum and glucose deprivation (SGD) in adipose-derived mesenchymal stem cells (AD-MSCs). We measured cell viability, proliferation, and apoptosis in cells experiencing SGD stress for 8 h with exposure to varying concentrations of ALCAR. Results showed that ALCAR protects cells against SGD stress by reducing apoptosis. Its protective effects are associated with reductions in cleaved caspase-3 and attenuation of apoptosis. Result showed that ALCAR exhibits protective effects against SGD-induced damage to AD-MSCs by enhancing the expression of survival signals and by decreasing the expression of death signals.

Keywords

, Acetyl, L, carnitine Mesenchymal stem cells Apoptosis Serum and glucose deprivation
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@article{paperid:1081225,
author = {Arash Abdolmaleki and Ghayour, Mohammad Bagher and Behnam Rassouli, Morteza},
title = {Protective effects of acetyl-l-carnitine against serum and glucose deprivation-induced apoptosis in rat adipose-derived mesenchymal stem cells},
journal = {Cell and Tissue Banking},
year = {2020},
month = {June},
issn = {1389-9333},
keywords = {Acetyl-L-carnitine Mesenchymal stem cells Apoptosis Serum and glucose deprivation},
}

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%0 Journal Article
%T Protective effects of acetyl-l-carnitine against serum and glucose deprivation-induced apoptosis in rat adipose-derived mesenchymal stem cells
%A Arash Abdolmaleki
%A Ghayour, Mohammad Bagher
%A Behnam Rassouli, Morteza
%J Cell and Tissue Banking
%@ 1389-9333
%D 2020

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