Title : ( Three novel complexes of copper: synthesis, characterization, crystal structure, HSA-binding and docking studies, and antiproliferative activity )
Authors: malihe zahmati eraj , Lars Eriksson , Mohammad Ramezani , Mona Alibolandi , Maryam Babaei , Amir SHokooh Saljooghi ,
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Abstract
The present study aims to synthesize new copper (II) complexes in the presence of maltol, sodium saccharin and 3-hydroxyflavone. Characterization of the structure of Cu (II) complexes was carried out by FTIR, CHN analysis and X-ray crystallography. Methods including fluorescence spectroscopy and molecular docking methods were applied to investigate the interaction of copper (II) complexes with human serum albumin. The cytotoxicity of complexes was screened for antiproliferative activity against human breast cancer cells (MCF-7), and cis-platin used as a comparative standard by MTT assay. The experimental results indicated that the fluorescence quenching of HSA by complexes 1-5 were a static quenching. Also, the results showed complex 3, [Cu(saccharin)(bpca)(H2O)], has higher cytotoxicity compared to other compounds and cis-platin.
Keywords
Cu(II) complexes; MTT assay; Docking study; HSA interactions.
@article{paperid:1081379,
author = {Zahmati Eraj, Malihe and Lars Eriksson and Mohammad Ramezani and Mona Alibolandi and Maryam Babaei and SHokooh Saljooghi, Amir},
title = {Three novel complexes of copper: synthesis, characterization, crystal structure, HSA-binding and docking studies, and antiproliferative activity},
journal = {Journal of the Iranian Chemical Society},
year = {2020},
volume = {18},
number = {4},
month = {September},
issn = {1735-207X},
pages = {765--783},
numpages = {18},
keywords = {Cu(II) complexes; MTT assay; Docking study; HSA interactions.},
}
%0 Journal Article
%T Three novel complexes of copper: synthesis, characterization, crystal structure, HSA-binding and docking studies, and antiproliferative activity
%A Zahmati Eraj, Malihe
%A Lars Eriksson
%A Mohammad Ramezani
%A Mona Alibolandi
%A Maryam Babaei
%A SHokooh Saljooghi, Amir
%J Journal of the Iranian Chemical Society
%@ 1735-207X
%D 2020
