Title : ( Allylphenols as a new class of human 15‐lipoxygenase‐1 inhibitors )
Authors: Seyed Jamal Alavi , Seyed Mohammad Seyedi , Satar Saberi , Hadi Safdari , Hossein Eshghi , Hamid Sadeghian ,
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Abstract
In this study, a series of mono- and diallylphenol derivative were designed, synthesized, and evaluated as potential human 15-lipoxygenase-1 (15-hLOX-1) inhibitors. Radical scavenging potency of the synthetic allylphenol derivatives was assessed and the results were in accordance with lipoxygenase (LOX) inhibition potency. It was found that the electronic natures of allyl moiety and para substituents play the main role in radical scavenging activity and subsequently LOX inhibition potency of the synthetic inhibitors. Among the synthetic compounds, 2,6-diallyl-4-(hexyloxy)phenol (42) and 2,6-diallyl-4-aminophenol (47) showed the best results for LOX inhibition (IC50 = 0.88 and 0.80 μM, respectively).
Keywords
, 15-hLOX-1, allylphenol, Claisen rearrangement, DPPH, MBTH
@article{paperid:1081643,
author = {Seyed Jamal Alavi and Seyedi, Seyed Mohammad and Satar Saberi and Hadi Safdari and Eshghi, Hossein and Hamid Sadeghian},
title = {Allylphenols as a new class of human 15‐lipoxygenase‐1 inhibitors},
journal = {Drug Development Research},
year = {2020},
volume = {82},
number = {2},
month = {October},
issn = {0272-4391},
pages = {259--266},
numpages = {7},
keywords = {15-hLOX-1; allylphenol; Claisen rearrangement; DPPH; MBTH},
}
%0 Journal Article
%T Allylphenols as a new class of human 15‐lipoxygenase‐1 inhibitors
%A Seyed Jamal Alavi
%A Seyedi, Seyed Mohammad
%A Satar Saberi
%A Hadi Safdari
%A Eshghi, Hossein
%A Hamid Sadeghian
%J Drug Development Research
%@ 0272-4391
%D 2020
