Title : ( Synthesis and antiproliferative assessments of new derivatives of isothiazolo[3,4-d]pyrimidine )
Authors: hamideh khoshniazi , Hossein Eshghi , Mona Tayarani-Najjaran , Zahra Tayarani-Najaran , Kayvan Saadat , Ali Shiri ,
Full TextAbstract
Various derivatives of 5-aryl-4-imino-3-(phenylamino)-4,5-dihydroisothiazolo[3,4-d]pyrimidines (3a-f) were synthesized. The synthesis has been done through treatment of 3-amino-4-cyano-5-(phenyla mino)isothiazole with various aryl isothiocyanates. The isothiazole skeleton was obtained by the reaction of malononitrile and phenyl isothiocyanate followed by chloramine treatment. Some of the synthesized dihydroisothiazolo[3,4-d]pyrimidines were tested against different cancer cell lines, including ACHN, HeLa, HL-60, MCF-7, and PC3. Malignant cells were cultured in RPMI medium and incubated with different concentrations of the mentioned compounds. Cell viability was assessed using the MTS assay. The cytotoxicities of the synthesized compounds are not significant and are probably safe for other biological use.
Keywords
, Isothiazolo[4, 3-d]pyrimidine; heterocyclization; aryl isothiocyanate; cytotoxicity; MTS assay
@article{paperid:1082076,
author = {Khoshniazi, Hamideh and Eshghi, Hossein and Mona Tayarani-Najjaran and Zahra Tayarani-Najaran and Saadat, Kayvan and Shiri, Ali},
title = {Synthesis and antiproliferative assessments of new derivatives of isothiazolo[3,4-d]pyrimidine},
journal = {Journal of Sulfur Chemistry},
year = {2020},
volume = {42},
number = {2},
month = {November},
issn = {1741-5993},
pages = {193--201},
numpages = {8},
keywords = {Isothiazolo[4;3-d]pyrimidine; heterocyclization; aryl isothiocyanate; cytotoxicity; MTS assay},
}
%0 Journal Article
%T Synthesis and antiproliferative assessments of new derivatives of isothiazolo[3,4-d]pyrimidine
%A Khoshniazi, Hamideh
%A Eshghi, Hossein
%A Mona Tayarani-Najjaran
%A Zahra Tayarani-Najaran
%A Saadat, Kayvan
%A Shiri, Ali
%J Journal of Sulfur Chemistry
%@ 1741-5993
%D 2020
