Title : ( An efficient diastereoselective synthesis of novel fused 5H-furo[2,3-d]thiazolo[3,2-a]pyrimidin-5-ones via one-pot three-component reaction )
Authors: Tooba Tabibi , Abbas Ali Esmaeili , Joel T. Mague ,
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Abstract
Herein, a convenient and efcient synthesis of 7-benzoyl-6-(aryl)-6,7-dihydro-5H-furo[2,3-d]thiazolo[3,2-a]pyrimidin-5-one derivatives was achieved from the reaction of isoquinolinium N-ylides, aromatic aldehydes, and heterocyclic 1,3-dicarbonyl compounds via one-pot three-component diastereoselective domino reaction in good-to-excellent yields. The advantages of this protocol are easily available starting materials, operational simplicity, and avoidance of hazardous organic solvents and catalyst. The synthesized products were characterized by IR, 1H NMR, 13C NMR and mass spectra. Additionally, the conclusive structure of target compounds was confrmed by X-Ray difraction analysis.
Keywords
, 7-benzoyl-6-(aryl)-6, 7-dihydro-5H-furo[2, 3-d]thiazolo[3, 2-a]pyrimidin-5-one · Phenacyl bromide · Isoquinoline · Thiazolo[3, 2-a]pyrimidin · Three-component reaction
@article{paperid:1083159,
author = {Tabibi, Tooba and Esmaeili, Abbas Ali and Joel T. Mague},
title = {An efficient diastereoselective synthesis of novel fused 5H-furo[2,3-d]thiazolo[3,2-a]pyrimidin-5-ones via one-pot three-component reaction},
journal = {Molecular Diversity},
year = {2021},
volume = {26},
number = {1},
month = {January},
issn = {1381-1991},
pages = {183--190},
numpages = {7},
keywords = {7-benzoyl-6-(aryl)-6;7-dihydro-5H-furo[2;3-d]thiazolo[3;2-a]pyrimidin-5-one · Phenacyl bromide ·
Isoquinoline · Thiazolo[3;2-a]pyrimidin · Three-component reaction},
}
%0 Journal Article
%T An efficient diastereoselective synthesis of novel fused 5H-furo[2,3-d]thiazolo[3,2-a]pyrimidin-5-ones via one-pot three-component reaction
%A Tabibi, Tooba
%A Esmaeili, Abbas Ali
%A Joel T. Mague
%J Molecular Diversity
%@ 1381-1991
%D 2021
