Title : ( Fast and efficient regioselective synthesis of a novel eight membered ring system, 5H-benzo[f]pyrimido[4,5-b][1,5]oxazocine )
Authors: Toktam Afrough , Hossein Eshghi ,
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Abstract
An efficient two-steps strategy for the regioselective synthesis of the benzo[f]pyrimido[4,5-b][1,5]oxazocine as a novel tricyclic system has been developed via inter- and intramolecular heterocyclization of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine and 2-aminobenzylalcohol in room temperature and short reaction times under mild conditions, followed amination with some secondary amines. 2D-NOESY and HMBC NMR spectroscopy was performed to gain the true regioisomer of the reaction, as well.
Keywords
, Heterocycles · Benzo[f]pyrimido[4, 5-b][1, 5]oxazocine · Regioselective synthesis · Heterocyclization · 2D-NOESY NMR
@article{paperid:1084612,
author = {Afrough, Toktam and Eshghi, Hossein},
title = {Fast and efficient regioselective synthesis of a novel eight membered ring system, 5H-benzo[f]pyrimido[4,5-b][1,5]oxazocine},
journal = {Monatshefte fur Chemie},
year = {2021},
volume = {152},
number = {4},
month = {March},
issn = {0026-9247},
pages = {475--479},
numpages = {4},
keywords = {Heterocycles · Benzo[f]pyrimido[4;5-b][1;5]oxazocine · Regioselective synthesis · Heterocyclization ·
2D-NOESY NMR},
}
%0 Journal Article
%T Fast and efficient regioselective synthesis of a novel eight membered ring system, 5H-benzo[f]pyrimido[4,5-b][1,5]oxazocine
%A Afrough, Toktam
%A Eshghi, Hossein
%J Monatshefte fur Chemie
%@ 0026-9247
%D 2021
