Carbohydrate Polymers, ( ISI ), Volume (266), Year (2021-8) , Pages (118111-118111)

Title : ( Targeted delivery system using silica nanoparticles coated with chitosan and AS1411 for combination therapy of doxorubicin and antimiR-21 )

Authors: fatemeh khatami , Maryam Moghaddam Matin , Noor Mohammad Danesh , Ahmad Reza Bahrami , Khalil Abnous , Seyed Mohammad Taghdisi ,

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Abstract

Herein, a novel targeted delivery system was developed for intracellular co-delivery of doxorubicin (DOX) as a chemotherapeutic drug, antimiR-21 as an oncogenic antagomiR. In this system, DOX was loaded into mesoporous silica nanoparticles (MSNs) and chitosan was applied to cover the surface of MSNs. AS1411 aptamer as targeting nucleolin and antimiR-21 were electrostatically attached onto the surface of the chitosan-coated MSNs and formed the final nanocomplex (AACS nanocomplex). The study of drug release was based on DOX release under pH 7.4 and 5.5. Cellular toxicity and cellular uptake assessments of AACS nanocomplex were carried out in nucleolin positive (C26, MCF-7, and 4T1) and nucleolin negative (CHO) cell lines using MTT assay and flow cytometry analysis, respectively. Also, Anti-tumor efficacy of AACS nanocomplex was evaluated in C26 tumorbearing mice. Overall, the results show that the combination therapy of DOX and antimiR-21, using AACS nanocomplex, could combat the cancer cell growth rate.

Keywords

, Colorectal cancer, Silica nanoparticles, Tumor, AS1411 aptamer, antimiR-21, Chitosan, Doxorubicin
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@article{paperid:1085034,
author = {Khatami, Fatemeh and Moghaddam Matin, Maryam and Noor Mohammad Danesh and Bahrami, Ahmad Reza and Khalil Abnous and Seyed Mohammad Taghdisi},
title = {Targeted delivery system using silica nanoparticles coated with chitosan and AS1411 for combination therapy of doxorubicin and antimiR-21},
journal = {Carbohydrate Polymers},
year = {2021},
volume = {266},
month = {August},
issn = {0144-8617},
pages = {118111--118111},
numpages = {0},
keywords = {Colorectal cancer; Silica nanoparticles; Tumor; AS1411 aptamer; antimiR-21; Chitosan; Doxorubicin},
}

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%0 Journal Article
%T Targeted delivery system using silica nanoparticles coated with chitosan and AS1411 for combination therapy of doxorubicin and antimiR-21
%A Khatami, Fatemeh
%A Moghaddam Matin, Maryam
%A Noor Mohammad Danesh
%A Bahrami, Ahmad Reza
%A Khalil Abnous
%A Seyed Mohammad Taghdisi
%J Carbohydrate Polymers
%@ 0144-8617
%D 2021

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