Title : ( Organobase-catalyzed one-pot three-component synthesis of novel pyrano[2,3-d][1,3]thiazolo[3,2-a]pyrimidine derivatives )
Authors: Abbas Ali Esmaeili , Fariba Mesbah , Mahdieh Zanzouei , Saeid Amini Ghalandarabad , Masoud Tasmimi , Azizollah Habibi , Ali Reza Fakhari , Amir Khojasteh Golmakani ,
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Abstract
Abstract An efcient, simple and fast procedure has been developed for the synthesis of a novel types of pyrano[2,3-d][1,3]thiazolo[3,2-a]pyrimidine derivatives through the one-pot three-component condensation reaction of 7-hydroxy-2,3-dihydro-5H-[1,3] thiazolo[3,2-a]pyrimidine-5-one, malononitrile and aromatic aldehydes in the presence DIPEA (N,N-diisopropylethylamine) as an available organo-base catalyst. This proposed procedure leads to the synthesis of desired products in short reaction times (5–10 min) and excellent isolated yields (90–94%)
Keywords
, DIPEA · 7-hydroxy-2, 3-dihydro-5H-[1, 3]thiazolo[3, 2-a]pyrimidine-5- one · Multicomponent reaction · Pyrimidine · Pyrano[2, 3-d][1, 3]thiazolo[3, 2-a] pyrimidine
@article{paperid:1085183,
author = {Esmaeili, Abbas Ali and Fariba Mesbah and مهدیه زنگوئی and Saeid Amini Ghalandarabad and Masoud Tasmimi and Azizollah Habibi and Ali Reza Fakhari and امیر خجسته نژاد گل مکانی},
title = {Organobase-catalyzed one-pot three-component synthesis of novel pyrano[2,3-d][1,3]thiazolo[3,2-a]pyrimidine derivatives},
journal = {Research on Chemical Intermediates},
year = {2021},
volume = {47},
number = {9},
month = {September},
issn = {0922-6168},
pages = {3537--3550},
numpages = {13},
keywords = {DIPEA · 7-hydroxy-2;3-dihydro-5H-[1;3]thiazolo[3;2-a]pyrimidine-5-
one · Multicomponent reaction · Pyrimidine · Pyrano[2;3-d][1;3]thiazolo[3;2-a]
pyrimidine},
}
%0 Journal Article
%T Organobase-catalyzed one-pot three-component synthesis of novel pyrano[2,3-d][1,3]thiazolo[3,2-a]pyrimidine derivatives
%A Esmaeili, Abbas Ali
%A Fariba Mesbah
%A مهدیه زنگوئی
%A Saeid Amini Ghalandarabad
%A Masoud Tasmimi
%A Azizollah Habibi
%A Ali Reza Fakhari
%A امیر خجسته نژاد گل مکانی
%J Research on Chemical Intermediates
%@ 0922-6168
%D 2021
