Toxicology Reports, Volume (8), Year (2021-1) , Pages (1280-1288)

Title : ( Subchronic neurotoxicity of diazinon in albino mice: Impact of oxidative stress, AChE activity, and gene expression disturbances in the cerebral cortex and hippocampus on mood, spatial learning, and memory function )

Authors: asieh karimani , Nasrin Ramezanigardaloud , Amir Afkhami Goli , Mohamad Hoein Nazem Shirazi , Hossein Nourani , Amir Moghadam Jafari ,

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Abstract

Diazinon (DZN) with prominent neurotoxic effects perturbs CNS function via multiple mechanisms. This investigation intends to explore mood, spatial learning, and memory dysfunction, acetylcholine esterase (AChE) activity, and neurodegeneration-related gene expression in the cortex and hippocampus regions of mice exposed to DZN for 63 consecutive days (subchronic exposure). Adult male albino mice were orally given sublethal DZN (DZNL = 0.1 mg/kg, DZNM = 1 mg/kg and DZNH = 10 mg/kg). All mice in the DZNH group died within 3 weeks postexposure. DZNL and DZNM caused body and brain weight loss (p < 0.05). Completing 9 weeks of DZN exposure, a marked decline in AChE activity and oxidative stress level was indicated in both brain regions (p < 0.05). Also, synaptophysin, vesicular acetylcholine transferase, and glutamate decarboxylase gene expressions were affected in both brain regions (p < 0.05). Furthermore, the present study revealed that DZN administration increased anxiety and depressive-like behaviors (p < 0.0001). Spatial learning and short- and long-memory were severely affected by DZNL and DZNM treatments (p < 0.0001). Taken together, subchronic exposure to low and medium doses of DZN can cause AChE inhibition, oxidative damage, and neurotransmitter disturbances in brain cells and induce neurodegeneration. These changes would impair mood, spatial learning, and memory function.

Keywords

Diazinon Neurodegenerative diseases Cerebral cortex Hippocampus Spatial learning Memo
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@article{paperid:1085342,
author = {Karimani, Asieh and Ramezanigardaloud, Nasrin and Afkhami Goli, Amir and Mohamad Hoein Nazem Shirazi and Nourani, Hossein and Moghadam Jafari, Amir},
title = {Subchronic neurotoxicity of diazinon in albino mice: Impact of oxidative stress, AChE activity, and gene expression disturbances in the cerebral cortex and hippocampus on mood, spatial learning, and memory function},
journal = {Toxicology Reports},
year = {2021},
volume = {8},
month = {January},
issn = {2214-7500},
pages = {1280--1288},
numpages = {8},
keywords = {Diazinon Neurodegenerative diseases Cerebral cortex Hippocampus Spatial learning Memo},
}

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%0 Journal Article
%T Subchronic neurotoxicity of diazinon in albino mice: Impact of oxidative stress, AChE activity, and gene expression disturbances in the cerebral cortex and hippocampus on mood, spatial learning, and memory function
%A Karimani, Asieh
%A Ramezanigardaloud, Nasrin
%A Afkhami Goli, Amir
%A Mohamad Hoein Nazem Shirazi
%A Nourani, Hossein
%A Moghadam Jafari, Amir
%J Toxicology Reports
%@ 2214-7500
%D 2021

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