Journal of Molecular Structure, ( ISI ), Volume (1247), No (1247), Year (2022-1) , Pages (131401-131401)

Title : ( Biological insights of a chiral hybrid-based γ-octamolybdate and proline )

Authors: mortaza tahmasebi heydarabad , Masoud Mirzaei Shahrabi , Maryam Moghaddam Matin , sonia iranpour , Joel T. Mague ,

Citation: BibTeX | EndNote


A new inorganic–organic hybrid based on proline functionalized γ-octamolybdate, [Co2(H2O)6(C5H9NO2)2(Mo8O26)]·2H2O (1) has been synthesized under hydrothermal conditions from the reaction of an Evans–Showell-type polyoxometalate (NH4)6[Co2Mo10H4O38], and proline. Characterization by infrared spectroscopy (IR), elemental analysis, diffuse reflectance spectroscopy (DRS) and single crystal X-ray diffraction methods revealed that 1 is a coordination polymer. Compound 1 undergoes a disorder under hydrothermal conditions. This is due to changes in the bond lengths and angles in isopolyanion and proline ligands compared to the non-disordered state. As a result, the molecule loses its symmetry and in the molecular state and in the crystalline phase, a chiral structure is obtained. The structure of proline allows the cobalt ion to not only have a covalent interaction with proline via the carboxyl group of proline, but also to act as a linker between two isoples, leading to a covalent chain. Then, adjacent 1-D chiral chains joined together by another Co-O covalent interactions to yield a 2-D supramolecular chiral layer. The topology of 1, can be rationalized as a two dimensional square lattice (sql) coordination network with point symbol {}2{48.66.8} in which, [Mo8O26(C5H9NO2)2]4− units act as linkers and the Co cations as nodes. Nonetheless, proline ligands have no direct role in expanding the structure as a 2-D covalent polymer. Anti-cancer activity of compound 1 was also evaluated to determine the IC50 values against two human-derived colon cancer and normal fibroblast cells. According to the results compound 1 exhibits both concentration- and time-dependent anti-proliferative effects on the cancerous cells.


Polyoxometalate; Octamolybdate; Chirality; Coordination polymer; MTT assay.
برای دانلود از شناسه و رمز عبور پرتال پویا استفاده کنید.

author = {Tahmasebi Heydarabad, Mortaza and Mirzaei Shahrabi, Masoud and Moghaddam Matin, Maryam and Iranpour, Sonia and Joel T. Mague},
title = {Biological insights of a chiral hybrid-based γ-octamolybdate and proline},
journal = {Journal of Molecular Structure},
year = {2022},
volume = {1247},
number = {1247},
month = {January},
issn = {0022-2860},
pages = {131401--131401},
numpages = {0},
keywords = {Polyoxometalate; Octamolybdate; Chirality; Coordination polymer; MTT assay.},


%0 Journal Article
%T Biological insights of a chiral hybrid-based γ-octamolybdate and proline
%A Tahmasebi Heydarabad, Mortaza
%A Mirzaei Shahrabi, Masoud
%A Moghaddam Matin, Maryam
%A Iranpour, Sonia
%A Joel T. Mague
%J Journal of Molecular Structure
%@ 0022-2860
%D 2022