Cancer Gene Therapy, Volume (28), No (9), Year (2021-9) , Pages (1-10)

Title : ( KRAS-related long noncoding RNAs in human cancers )

Authors: MAHSA SALIANI , Amin Mirzaiebadizi , Ali Javadmanesh , Akram Siavoshi , Mohammad Reza Ahmadian ,

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KRAS is one of the most widely prevalent proto-oncogenes in human cancers. The constitutively active KRAS oncoprotein contributes to both tumor onset and cancer development by promoting cell proliferation and anchorage-independent growth in a MAPK pathway-dependent manner. The expression of microRNAs (miRNAs) and the KRAS oncogene are known to be dysregulated in various cancers, while long noncoding RNAs (lncRNAs) can act as regulators of the miRNAs targeting KRAS oncogene in different cancers and have gradually become a focus of research in recent years. In this review article, we summarize recent advances in the research on lncRNAs that have sponging effects on KRAS-targeting miRNAs as crucial mediators of KRAS expression in different cell types and organs. A deeper understanding of lncRNA function in KRAS-driven cancers is of major fundamental importance and will provide a valuable clinical tool for the diagnosis, prognosis, and eventual treatment of cancers.


, KRAS, LncRNA, Cancer,
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author = {SALIANI, MAHSA and Amin Mirzaiebadizi and Javadmanesh, Ali and Akram Siavoshi and Mohammad Reza Ahmadian},
title = {KRAS-related long noncoding RNAs in human cancers},
journal = {Cancer Gene Therapy},
year = {2021},
volume = {28},
number = {9},
month = {September},
issn = {0929-1903},
pages = {1--10},
numpages = {9},
keywords = {KRAS; LncRNA; Cancer;},


%0 Journal Article
%T KRAS-related long noncoding RNAs in human cancers
%A Amin Mirzaiebadizi
%A Javadmanesh, Ali
%A Akram Siavoshi
%A Mohammad Reza Ahmadian
%J Cancer Gene Therapy
%@ 0929-1903
%D 2021