Hybrid metal–polymer-coordinated complex, as a class of supramolecular coordinated complex, represents a great opportunity for the development of the multipurpose intelligent system of nanomedicine in drug delivery. These structures and their interesting functions are created after the self-assembly process and coordination bond formation between diferent metal ions and polymers. There is an important diference between metal–organic framework (MOF) and metal polymercoordinated complex (MPC). MPCs are convergent structures made of metal and polymeric linkers’ combination in 1D, 2D and 3D architectures while MOFs are divergent 3D network structures with metal cores and organic ligands linkers. Until now, many reviews have been published about MOF-based systems while there is no comprehensive review on MPCs. Moreover, the MPCs have exhibited potential nano-chemistry properties to be utilized in nanomedicine applications as smart and multifunction nanovesicles for drug delivery. In this review, the MPC architectures, their synthesis process and their applications in drug delivery are described. The advantages and disadvantages of MPC are summarized. We also categorized smart MPCs for on-demand drug release and intelligent delivery.

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