Colon and gastric cancers are among the top 5 most common cancers worldwide. The high mortality rate of these malignancies has made it crucial to improve clinical outcomes by exploring new chemical agents. Accordingly, the aim of present study was to evaluate toxic activity of exopolysaccharides (EPS) from luminescent Vibrio sp. VLC on human colon and gastric cancer cells. After biosynthesis, extraction and purification of EPS, LoVo and MKN45 cells, as well as normal fibroblasts, were treated with 25, 50, 100 and 200 μg/ml EPS and their viability was evaluated by alamarBlue assay. Results revealed that EPS from luminescent Vibrio sp. VLC induced its toxic effects in a time- and dose-dependent manner, as 24 h treatment of colon and gastric cancer cells reduced viability more than 48 h treatment. Furthermore, lowest viability of both cancer cell lines was detected after treatment with 200 μg/ml EPS

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