Soft X-ray emerging from INTRABEAM along with different spherical applicators diameter are employed for low energy X-ray intraoperative radiotherapy. In this work, a Monte Carlo model of INTRAMBEAM and spherical applicators was simulated by GEANT4 toolkit and dosimeteric characteristics of bare prob and deferent spherical applicators were evaluated quantitatively. After the calculation of dosimeteric features such as percent depth dose (PDD) and anisotropy, they were compared with manufacture’s reported data (Carl Zeiss, Germany). There was a good agreement between the simulated and reported PDDs by manufacture. In addition the acquired anisotropies were also within the standard recommended criteria by the manufacture. Eventually, usefulness of GEANT4 toolkit for simulation of INTRABEAM machine and its dedicated spherical applicators for commissioning and evaluation of dosimeteric characteristics, was confirmed in current study

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