Proton therapy is one of the most important ways of cancer treatment that is widely used. Positron emitter isotopes are produced by non-elastic nuclear interaction of protons with target nuclei such as 12C, 14N and 16O. PET imaging relies upon the detection of photons, produced in the annihilation of positron-electron. Therefore, these radioisotopes are used for monitoring of dose distribution in PET imaging. In this paper, the most common positron emitter particles ( 11C, 13N, 15O, 18F ) is evaluated by GEANT4 Monte Carlo toolkit. The findings show

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