The bone metastasis is one of the important causes of cancers such as prostate, breast, kidney, liver and so on. Usually to relieve bone pain caused by cancer, the Re-HEDP and Sm-EDTMP Radionuclides are used. The purpose of this study, is the dose calculation of 153Sm and 186Re Radioisotope in the spine by using MCNPX Monte Carlo code. So far no calculations have been done on the accurate geometry of spine. The method of this study is the simulation of dose absorption in the spine with tracking the radioisotope in the surface and volume of bone. In this study, samples of spine were completely simulated. One of the important results obtained from this research is that, for cancerous tumors that have spread to the bone surface, using of 153Sm is better than 186Re radioisotope.

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