Title : ( An Efficient One-Pot and Regioselective Synthesis of Novel Heterocyclic Systems of 5,6-Dihydrobenzo[b]Pyrimido[5,4-f][1,4]Oxazepine )
Authors: Fahimeh Assadzadeh , Hossein Eshghi , Toktam Afrough ,
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Abstract
An efficient and convenient one-pot two-step process for the regioselective synthesis of the novel tricyclic system 2-chloro-4-methyl-5,6-dihydrobenzo[ b]pyrimido[5,4-f][1,4] oxazepine has been described via heterocyclization of 5-(chloromethyl)-2,4-dichloro-6-methylpyrimidine and 2-aminophenol under mild condition followed by reaction with the various secondary amine in moderate to good yields and short time (4a-f).
Keywords
, 5, 6-Dihydrobenzo[b]pyrimido[5, 4-f][1, 4]oxazepine; regioselective; heterocyclization; secondary amine
@article{paperid:1089040,
author = {Assadzadeh, Fahimeh and Eshghi, Hossein and Afrough, Toktam},
title = {An Efficient One-Pot and Regioselective Synthesis of Novel Heterocyclic Systems of 5,6-Dihydrobenzo[b]Pyrimido[5,4-f][1,4]Oxazepine},
journal = {Polycyclic Aromatic Compounds},
year = {2022},
volume = {43},
number = {2},
month = {February},
issn = {1040-6638},
pages = {1557--1565},
numpages = {8},
keywords = {5;6-Dihydrobenzo[b]pyrimido[5;4-f][1;4]oxazepine; regioselective; heterocyclization; secondary amine},
}
%0 Journal Article
%T An Efficient One-Pot and Regioselective Synthesis of Novel Heterocyclic Systems of 5,6-Dihydrobenzo[b]Pyrimido[5,4-f][1,4]Oxazepine
%A Assadzadeh, Fahimeh
%A Eshghi, Hossein
%A Afrough, Toktam
%J Polycyclic Aromatic Compounds
%@ 1040-6638
%D 2022
