Title : ( Catalyst-free Facile Synthesis of Novel Fused Spiro[benzo[4,5]thiazolo[3,2-a]pyrano[2,3-d]pyrimidine-4,3'-indoline]-3-carbonitrile Derivatives via One-pot Three-Component Reaction )
Authors: maryam khalili , Abbas Ali Esmaeili ,
Full TextAbstract
In summcatalyst-freeary, a and facile procedure has been described for the synthesis of novel spiro heterocycles 6 via a one-pot three-component condensation reaction among dione 3, isatins and malononitrile in ethanol/water. The short reaction times, high isolated yields and absence of any need for catalyst are advantages of this method. We hope that the ready availability of these new spiro heterocycles will spur the further investigation of their intriguing structures and potential for biological activity.
Keywords
, catalyst-free, spiro-heterocycles, isatin, malononitrile,
@article{paperid:1089321,
author = {Khalili, Maryam and Esmaeili, Abbas Ali},
title = {Catalyst-free Facile Synthesis of Novel Fused Spiro[benzo[4,5]thiazolo[3,2-a]pyrano[2,3-d]pyrimidine-4,3'-indoline]-3-carbonitrile Derivatives via One-pot Three-Component Reaction},
journal = {Organic Preparations and Procedures International},
year = {2022},
volume = {54},
number = {2},
month = {March},
issn = {0030-4948},
pages = {145--156},
numpages = {11},
keywords = {catalyst-free; spiro-heterocycles; isatin; malononitrile;},
}
%0 Journal Article
%T Catalyst-free Facile Synthesis of Novel Fused Spiro[benzo[4,5]thiazolo[3,2-a]pyrano[2,3-d]pyrimidine-4,3'-indoline]-3-carbonitrile Derivatives via One-pot Three-Component Reaction
%A Khalili, Maryam
%A Esmaeili, Abbas Ali
%J Organic Preparations and Procedures International
%@ 0030-4948
%D 2022
