Canine Transmissible Venereal Tumor (TVT) is a type of contagious and life-threatening cancer in which that neoplastic cells distributed via coitus in dogs. A 14-year-old, intact, male, Siberian husky weighting 21 kg, was referred to the Veterinary Medicine Hospital of Ferdowsi Univer- sity of Mashhad|, with sign of dyspnea, epistaxis, mucosal discharge from aoral cavity and anorexia. According to the given history, the dog had not improved after several antibiotic therapy courses and wound management in the past month. Clinical examination of the head and oral cavity showed, unilateral nasal hemorrhage, swelling of the phar- ynx and larynx, and purulent discharge from a defect (3.9cm x 2.3cm) in a mass on the soft palate. Granulomatous inflammation was also found in the radiological evaluation of the pharynx and larynx. In or- der to precise evaluation of the lesion, the animal underwent general anesthesia. After wound debridement and lavage, a smear was taken from the tissue of the affected area and also tissue samples were also obtained for the histopathological assessments. A gastric tube was in- serted to prevent contamination and anorexia due to the oral leison. Ex- amination of the smear demonestrated the presence of a large number of round cells with basophilic cytoplasm containing intracytoplasmic vacuoles, eccentric round nucleus with distinct nuclei, that confirmed the presence of TVT. Vincristine sulfate and broad-spectrum antibi- otics were administered. The mass was significantly smaller (0.75cm x 0.5cm) and the clinical symptoms were greatly reduced after two weeks, treatment. Side effects were not manifested during the treat- ment period. Our report is one of the few findings of primary TVT with soft palate involvement. Primary extragenital involvements such as cu- taneous, ocular, nasal, oral lesions are rare but this neoplasm should be listed in differential diagnoses of extragenital masses in dogs. Neuter- ing of affected and healthy dogs may prevent further transmission of

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