Introduction: Due to the increasing rate of COVID-19 disease, experiencing high levels of death anxiety is predictable all over the world. Therefore, the aim of the present study was to investigate the prediction path of death anxiety through fear of COVID-19, neuroticism, behavioral inhibition system, and uncertainty intolerance. Materials and Methods: The research design of this study was descriptive-correlation and of structural equations type. The statistical population of this study included Iranian adults from whom, 400 were selected by the convenient sampling method. Data were collected in July and August 2020 using the Templer Death Anxiety Scale (TDAS), Fear of COVID-19 Scale (FCV-19S), Neo Five-Factor Inventory short form questionnaire (NEO-FFI), the Behavioral Inhibition System/Behavioral Activation System Scale (BIS/BAS Scale), and Intolerance of Uncertainty Scale, in Mashhad- Iran. Data analysis was performed using the Pearson correlation method, path analysis, SPSS version 26, and AMOS version 24. Results: The results showed that there are significant relationships between death anxiety with fear of COVID-19 (P< 0.01), and neuroticism (P< 0.01); between behavioral inhibition system with intolerance of uncertainty (P< 0.01); and between Intolerance of uncertainty with death anxiety (P< 0.01). Also, the path of predicting death anxiety through neuroticism, behavioral inhibition system and intolerance of uncertainty was confirmed at the level of 0.001 and the path was significant. Conclusion: Based on the findings, death anxiety is predicted by the path of fear of COVID-19, neuroticism, behavioral inhibition system, and uncertainty intolerance.

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