Introduction: Individuals with schizophrenia significantly show impaired social cognition, which manifests as difficulties in identifying emotions, feeling connected to others, inferring others\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\' thoughts, and reacting emotionally to others. Extrinsic and intrinsic processes for monitoring, evaluating, and modifying emotional reactions, their intensive and temporal features, to accomplish one’s goals are Emotion regulation (ER). The process model in which the various strategies are allocated in terms of their direct impact on the emotion-generative process guided by distinct strategies, including reappraisal, suppression, and distraction. Methods: This systematic review aimed to identify studies assessing the social processes impaired in schizophrenia. To identify articles with original data published after 2015 until 2021. A total of 125 publications were identified, of which 7 met the inclusion criteria. Results: : Emotional abnormalities and Aberrant emotion processing are well-established components of schizophrenia. Also, there is consistent evidence for aversion to positive and neutral stimuli in schizophrenia which could be valence or task difficulty-dependent. Several functional magnetic resonance (fMRI) studies illustrated lower activation of emotional stimuli than neutral stimuli in schizophrenia patients. These findings mainly were reported for the bilateral amygdala about aversive stimuli and facial emotion expressions (e.g., explicit processing). Under-recruitment of other regions to emotion-related stimuli was also reported, such as the hippocampus, early visual processing regions, and frontal cortices. Amygdala hyperresponsivity has been demonstrated in the neurodevelopmental approach, in which a functional loss of parvalbumin interneurons in the hippocampus is associated with increased dopaminergic activity in the striatum. This systematic review of studies used emotion-processing task paradigms in individuals with schizophrenia. Image-based studies compared to controls showed decreased neural responses to emotion, particularly in the amygdala and anterior cingulate cortex. Mostly, there were no significant differences between participants and controls, but a high degree of heterogeneity was identified across the studies. Conclusion: However, the putative role of emotion processing in schizophrenia emergence and the underlying neurobiology remains unclear, particularly with results showing that deficits are predictive of functional outcomes and antipsychotic medication does not adequately treat emotion-related deficiencies in schizophrenia. Either of the three response patterns could be present in different individuals and collectively show amygdala hypoactivation. Future studies assessing activation to the neutral condition in healthy controls are needed.

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