Title : ( Editorial: Identifying the isoform-specific roles of RAS paralogs in health and disease )
Authors: Saeideh Nakhaeirad ,
Full TextAbstract
The RAS family of small GTPases is categorized into eight groups of paralogs: RAS, RAL, RRAS, RIT, RAP, RHEB, RASD, ERAS, and DIRAS. Although the prototypes of the RAS family, KRAS, NRAS, and HRAS, are well-known for their role in human carcinogenesis, RAS proteins also play fundamental roles in normal human development, by regulating a wide array of cellular processes, including survival, growth, adhesion, migration, differentiation and fate decision (Nakhaei-Rad et al., 2018). The dysregulation of the RAS signaling pathway leads to cancer as well as to developmental disorders, named RASopathies, connected with cardiac, skin, neuronal, and metabolic phenotypes.
Keywords
, RAS, effector, isoform, paralog, cancer, Rasopathy
@article{paperid:1094114,
author = {Nakhaeirad, Saeideh},
title = {Editorial: Identifying the isoform-specific roles of RAS paralogs in health and disease},
journal = {Frontiers in Cell and Developmental Biology},
year = {2023},
volume = {11},
number = {1199356},
month = {April},
issn = {2296-634X},
pages = {1--3},
numpages = {2},
keywords = {RAS; effector; isoform; paralog; cancer; Rasopathy},
}
%0 Journal Article
%T Editorial: Identifying the isoform-specific roles of RAS paralogs in health and disease
%A Nakhaeirad, Saeideh
%J Frontiers in Cell and Developmental Biology
%@ 2296-634X
%D 2023
