The RAS family of small GTPases is categorized into eight groups of paralogs: RAS, RAL, RRAS, RIT, RAP, RHEB, RASD, ERAS, and DIRAS. Although the prototypes of the RAS family, KRAS, NRAS, and HRAS, are well-known for their role in human carcinogenesis, RAS proteins also play fundamental roles in normal human development, by regulating a wide array of cellular processes, including survival, growth, adhesion, migration, differentiation and fate decision (Nakhaei-Rad et al., 2018). The dysregulation of the RAS signaling pathway leads to cancer as well as to developmental disorders, named RASopathies, connected with cardiac, skin, neuronal, and metabolic phenotypes.

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