Using nanofluids is an applicable way of improving heat transfer. Besides, manipulating internal flows using baffles on the walls is so common in industrial energy process for increasing its thermal efficiency. Methods Two-phase numerical study of CuO-water nanofluid developing flow inside a constant heat flux channel with consecutive baffles has been done by a modified Lagrangian solver in OpenFOAM. In this way, the thermophoretic force was implemented as a new submodel into OpenFOAM’s library. The effects of various parameters consist of baffle’s height and spacing as well as Reynolds number and nanoparticle’s volume concentration were analyzed on the pressure drop, heat transfer, and particle’s deposition inside the channel. Significant Findings It was observed that increasing the baffle height ratio A/H or decreasing the baffle spacing ratio B/H, considerably increases heat transfer and pressure drop as well as particle deposition inside the channel. Besides, some vortexes were generated after each baffle, having lower concentration than the other regions of the channel. Finally, particle deposition efficiency of different surfaces of the channel was compared with each other and it was reported that particle deposition on the baffles is noticeably higher than the walls of the channel.

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