Background: Immune factors can also cause skin wounds, which is why people with immune skin diseases frequently have ulcers. For example, allergic vasculitis is accompanied by NF-B pathway activation and increases in IL-6 and TNF, whereas dermatomyositis exhibits a proinflammatory phenotype with increased amounts of IL-10 and IL-6 after TLR7 activation. Because immune diseases are the main cause of wound formation in these circumstances, immunotherapy is essential for wound healing. In this systematic review, the anti-inflammatory capabilities of nanomaterials were discussed. Methods: Nine databases (PubMed, Scopus, Google Scholar, Cochrane Library, Magiran, SID, Medline, Embase, and Lilacs) were searched for published articles on the potential treatment of nanomaterials for immune wounds from January 2000 to January 2023. Fifteen affiliated articles with complete abstracts were included in this study. All data were extracted from interconnected papers and analyzed with R version 4.2.1 artificial intelligence software. Results: AgNPs and nanofibers can decrease IL-6, IL-1, and TNF- expression, while metal nanomaterials, including TiO2 NPs and ZnO NPs, can inhibit the NFB and TLR pathways by activating the arginase 1 and transcription factors PPAR. Nanomaterials support the phenotypic transformation of macrophages and regulate the expression of inflammatory factors in the wound during the immunomodulatory stage. Treg cells aid in the maintenance of peripheral immune tolerance in the body by secreting anti-inflammatory factors or exosome vesicles that promote T cell apoptosis and suppress T cell proliferation. Conclusion: As a consequence, it is possible to hypothesize that nanomaterials could play a role in regulating immunological skin wound inflammation through the aforementioned pathways, but more research is required.

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